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  • 标题:Repurposing the anthelmintic drug niclosamide to combat Helicobacter pylori
  • 本地全文:下载
  • 作者:Nagendran Tharmalingam ; Jenna Port ; Dawilmer Castillo
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2018
  • 卷号:8
  • 期号:1
  • 页码:3701
  • DOI:10.1038/s41598-018-22037-x
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:(5) assay indicating that the mechanism of action of the anti-H. pylori activity of niclosamide was the disruption of H. pylori proton motive force. Niclosamide was effective in the Galleria mellonella-H. pylori infection model (p = 0.0001) and it can be develop further to combat H. pylori infection. However, results need to be confirmed with other H. pylori and clinical strains.
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