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  • 标题:Elastic net regularized regression for time-series analysis of plasma metabolome stability under sub-optimal freezing condition
  • 本地全文:下载
  • 作者:Gerard Bryan Gonzales ; Sarah De Saeger
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2018
  • 卷号:8
  • 期号:1
  • 页码:3659
  • DOI:10.1038/s41598-018-21851-7
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:= 0.7893 [negative mode], p-value < 0.00001). Based on the temporal profiles of the extracted metabolites by the model, results show only minimal deterioration of the plasma metabolome at -20 °C up to 1 month. However, majority of the changes appeared at around 12-15 days of storage. This allows scientists to better plan logistics and storage strategies for samples obtained from low-resource settings, where -80 °C storage is not guaranteed.
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