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  • 标题:Inactivation of TRPM7 kinase in mice results in enlarged spleens, reduced T-cell proliferation and diminished store-operated calcium entry
  • 本地全文:下载
  • 作者:Pavani Beesetty ; Krystyna B. Wieczerzak ; Jennifer N. Gibson
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2018
  • 卷号:8
  • 期号:1
  • 页码:3023
  • DOI:10.1038/s41598-018-21004-w
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:elevations elicited by anti-CD3 antibody were diminished in KD mutant T cells and SOCE measured in activated KD splenocytes was reduced. These results demonstrate that a functional TRPM7 kinase supports robust SOCE, blastogenesis and proliferation, whereas its inactivation suppresses these cellular events.
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