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  • 标题:Compositional marker in vivo reveals intramyocellular lipid turnover during fasting-induced lipolysis
  • 本地全文:下载
  • 作者:Ajay Thankamony ; Graham J. Kemp ; Albert Koulman
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2018
  • 卷号:8
  • 期号:1
  • 页码:2750
  • DOI:10.1038/s41598-018-21170-x
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:ratio indicated a less unsaturated IMCL pool after fasting, and this compositional change related inversely to IMCL baseline composition, suggesting a selective efflux of unsaturated shorter-chain FA from the IMCL pool. This novel in vivo evidence reveals IMCL turnover during extended fasting, consistent with the concept of a flexible, responsive myocellular lipid store. There were also differences between soleus and tibialis anterior in basal IMCL composition and in response to fasting. We discuss the potential of this marker for providing insights into normal physiology and mechanisms of disease.
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