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  • 标题:Quantitative Magnetization Transfer in Monitoring Glioblastoma (GBM) Response to Therapy
  • 本地全文:下载
  • 作者:Hatef Mehrabian ; Sten Myrehaug ; Hany Soliman
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2018
  • 卷号:8
  • 期号:1
  • 页码:2475
  • DOI:10.1038/s41598-018-20624-6
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:were able to differentiate the two cohorts with [Formula: see text] providing the best separation (relative [Formula: see text] = 1.34 ± 0.21, relative [Formula: see text] = 1.07 ± 0.08, p = 0.031). Thus, qMT characteristics of GBM are more sensitive to treatment effects compared to clinically used metrics. qMT could assess tumor aggressiveness and identify early progressors even before the treatment. Changes in qMT parameters within the first 14 days of the treatment were capable of separating early progressors from non-progressors, making qMT a promising biomarker to guide adaptive radiotherapy for GBM.
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