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  • 标题:Canagliflozin, an SGLT2 inhibitor, attenuates the development of hepatocellular carcinoma in a mouse model of human NASH
  • 本地全文:下载
  • 作者:Kumiko Shiba ; Kyoichiro Tsuchiya ; Chikara Komiya
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2018
  • 卷号:8
  • 期号:1
  • 页码:2362
  • DOI:10.1038/s41598-018-19658-7
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:-induced upregulation of genes related to NADPH oxidase in 3T3-L1 adipocytes, and that of Il6, Tgfb, and Pdgfb in RAW264.7 cells. This study provides evidence that SGLT2 inhibitors represent the unique class of drugs that can attenuate or delay the onset of NASH and eventually hepatocellular carcinoma, at least partly, through "healthy adipose expansion".
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