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  • 标题:PCSK9 induces a pro-inflammatory response in macrophages
  • 本地全文:下载
  • 作者:Chiara Ricci ; Massimiliano Ruscica ; Marina Camera
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2018
  • 卷号:8
  • 期号:1
  • 页码:2267
  • DOI:10.1038/s41598-018-20425-x
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:, respectively). Finally, a positive correlation between PCSK9 and TNF-α plasma levels of healthy adult subjects (males 533, females 537) was observed (B = 8.73, 95%CI 7.54 ÷ 9.93, p < 0.001). Taken together, the present study provides evidence of a pro-inflammatory action of PCSK9 on macrophages, mainly dependent by the LDLR.
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