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  • 标题:A unique inbred rat strain with sustained cephalic hypersensitivity as a model of chronic migraine-like pain
  • 本地全文:下载
  • 作者:Gordon Munro ; Steffen Petersen ; Inger Jansen-Olesen
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2018
  • 卷号:8
  • 期号:1
  • 页码:1836
  • DOI:10.1038/s41598-018-19901-1
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:receptor agonist) and olcegepant (CGRP receptor antagonist) could completely reverse cephalic hypersensitivity using a within subject cross-over paradigm. Our findings indicate that STA rats actually possess a phenotype indicative of migraine chronicity which is exquisitely sensitive to migraine therapeutics. This unique strain could prove to be an invaluable resource in preclinical migraine drug discovery.
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