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  • 标题:Anti-glioma Natural Products Downregulating Tumor Glycolytic Enzymes from Marine Actinomycete Streptomyces sp. ZZ406
  • 本地全文:下载
  • 作者:Mengxuan Chen ; Weiyun Chai ; Tengfei Song
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2018
  • 卷号:8
  • 期号:1
  • 页码:72
  • DOI:10.1038/s41598-017-18484-7
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:values of 4.7 to 8.1 μM, high selectivity index (>12.3 to 21.3), and good stability in human liver microsomes. Western blot analysis revealed that compound 1 remarkably downregulated the expressions of several important glioma glycolytic enzymes. The data from this study suggested that compound 1 might have potential as a novel anti-glioma agent to be further investigated.
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