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  • 标题:Novel Ridaifen-B Structure Analog Induces Apoptosis and Autophagy Depending on Pyrrolidine Side Chain
  • 本地全文:下载
  • 作者:Takumi Iwasawa ; Takahisa Shinomiya ; Nozomi Ota
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:2019
  • 卷号:42
  • 期号:3
  • 页码:401-410
  • DOI:10.1248/bpb.b18-00643
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:Sea‐level rise along low‐lying coasts of the world's passive continental margins should, on average, drive net shoreline retreat over large spatial scales (>102 km). A variety of natural physical factors can influence trends of shoreline erosion and accretion, but trends in recent rates of shoreline change along the U.S. Atlantic Coast reflect an especially puzzling increase in accretion, not erosion. A plausible explanation for the apparent disconnect between environmental forcing and shoreline response along the U.S. Atlantic Coast is the application, since the 1960s, of beach nourishment as the predominant form of mitigation against chronic coastal erosion. Using U.S. Geological Survey shoreline records from 1830–2007 spanning more than 2,500 km of the U.S. Atlantic Coast, we calculate a mean rate of shoreline change, prior to 1960, of −55 cm/year (a negative rate denotes erosion). After 1960, the mean rate reverses to approximately +5 cm/year, indicating widespread apparent accretion despite steady (and, in some places, accelerated) sea‐level rise over the same period. Cumulative sediment input from decades of beach‐nourishment projects may have sufficiently altered shoreline position to mask “true” rates of shoreline change. Our analysis suggests that long‐term rates of shoreline change typically used to assess coastal hazard may be systematically underestimated. We also suggest that the overall effect of beach nourishment along of the U.S. Atlantic Coast is extensive enough to constitute a quantitative signature of coastal geoengineering and may serve as a bellwether for nourishment‐dominated shorelines elsewhere in the world.
  • 关键词:ridaifen;tamoxifen;apoptosis;autophagy;mitophagy
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