Stress can cause a negative effect on the psychological condition and affect the overall job performance of an employee. The aim of this study is to examine the relationship between job stress and job performance among administrative staff in Selangor (state of Malaysia) Hospitals. Probability sampling techniques were used as the name of the respondents and a simple random sampling was used to conduct this study. List of Government Hospitals has been obtained from the official website and the directory of Ministry of Health Malaysia. The results show that all the variables such as work stress, workload, work-life conflict time pressure, and social pressure significantly influence the job performance of Hospital administrative staffs. The research results help to improve employee performance by understanding the behavior and attitudes of hospital staff against work stress. The implication of the study has been explaining in detail with limitation and future research study for his current research.