摘要：Background: Recurrent pregnancy loss (RPL) is a heterogeneous condition consisting of three or more consecutive abortions before 20th week of gestation. Despite extensive research on the causative effects of RPL, approximately 50% - 60% of RPLs are still idiopathic. Although an increasing number of prospective studies have been conducted with sufficient power to investigate the association between various thrombophilias and RPL, some controversy still remains toward screening for thrombophilia in women with RPL. Objectives: The aim of this study was to investigate the association between recurrent pregnancy loss and polymorphism in factor-XI (A > T) gene in Iranian Azeri women. Methods: This is an association study with a case-control design. The study participants consisted of 320 women with RPL from Iranian Azeri origin. The control group comprised 320 age- and ethnically-matched healthy women in the reproductive age. Genomic DNA was extracted from the whole blood and genotyping was performed using PCR amplification followed by restriction fragment length polymorphism (RFLP) analysis. Results: The genotype frequencies in the case group were 54/68% AA, 45/31% AT, and 0/9% TT, while the frequencies in the control group were 52/18% AA, 47/32% AT, and 0/6% TT. No significant association was found between factor XI rs3756008 polymorphism and RPL (P > 0.05). Conclusions: There is no significant association between factor XI rs3756008 (A > T) polymorphism and RPL among Iranian Azeri women.
