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文章基本信息

  • 标题:A Graph Based Framework to Model Virus Integration Sites
  • 本地全文:下载
  • 作者:Raffaele Fronza ; Alessandro Vasciaveo ; Alfredo Benso
  • 期刊名称:Computational and Structural Biotechnology Journal
  • 印刷版ISSN:2001-0370
  • 出版年度:2016
  • 卷号:14
  • 页码:69-77
  • DOI:10.1016/j.csbj.2015.10.006
  • 语种:
  • 出版社:Computational and Structural Biotechnology Journal
  • 摘要:With next generation sequencing thousands of virus and viral vector integration genome targets are now under investigation to uncover specific integration preferences and to define clusters of integration, termed common integration sites (CIS), that may allow to assess gene therapy safety or to detect disease related genomic features such as oncogenes.
  • 关键词:Gene therapy ; Systems biology ; Genomics ; Insertional mutagenesis
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