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  • 标题:KENeV: A web-application for the automated reconstruction and visualization of the enriched metabolic and signaling super-pathways deriving from genomic experiments
  • 本地全文:下载
  • 作者:Eleftherios Pilalis ; Theodoros Koutsandreas ; Ioannis Valavanis
  • 期刊名称:Computational and Structural Biotechnology Journal
  • 印刷版ISSN:2001-0370
  • 出版年度:2015
  • 卷号:13
  • 页码:248-255
  • DOI:10.1016/j.csbj.2015.03.009
  • 语种:
  • 出版社:Computational and Structural Biotechnology Journal
  • 摘要:Gene expression analysis, using high throughput genomic technologies,has become an indispensable step for the meaningful interpretation of the underlying molecular complexity, which shapes the phenotypic manifestation of the investigated biological mechanism. The modularity of the cellular response to different experimental conditions can be comprehended through the exploitation of molecular pathway databases, which offer a controlled, curated background for statistical enrichment analysis. Existing tools enable pathway analysis, visualization, or pathway merging but none integrates a fully automated workflow, combining all above-mentioned modules and destined to non-programmer users.
  • 关键词:KEGG ; Enrichment analysis ; Molecular pathways ; Gene expression ; Microarrays ; Next generation sequencing
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