期刊名称：Computational and Structural Biotechnology Journal
印刷版ISSN：2001-0370
出版年度：2014
卷号：12
期号：20-21
页码：26-33
DOI：10.1016/j.csbj.2014.10.001
语种：
出版社：Computational and Structural Biotechnology Journal
摘要：Amoebiasis caused by the gastrointestinal parasite Entamoeba histolytica has diverse disease outcomes. Study of genome and evolution of this fascinating parasite will help us to understand the basis of its virulence and explain why, when and how it causes diseases. In this review, we have summarized current knowledge regarding evolutionary genomics of E. histolytica and discussed their association with parasite phenotypes and its differential pathogenic behavior. How genetic diversity reveals parasite population structure has also been discussed. Queries concerning their evolution and population structure which were required to be addressed have also been highlighted. This significantly large amount of genomic data will improve our knowledge about this pathogenic species of Entamoeba.
关键词：Genetic polymorphism ; Disease outcome ; Genetic recombination ; Genotyping ; Short tandem repeat loci ; Single nucleotide polymorphism
