摘要:The San Francisco, California–based HIV Homeless-Health Outreach Mobile Engagement (HHOME) program aims to improve health and housing outcomes for multiply diagnosed people experiencing chronic homelessness whom the HIV care system has failed to reach. From 2014 to 2017, HHOME’s mobile multidisciplinary team served 106 clients. Viral suppression increased from 23.6% to 60%, and 73.8% obtained permanent supportive housing (n = 61). System-level changes included the adoption of city-wide standardized acuity assessment tools HIV Care Coordination Taskforce by community partners. This article highlights HHOME’s core components and its public health implications. The San Francisco, California, Department of Public Health’s HIV Homeless-Health Outreach Mobile Engagement (HHOME) project is a mobile, multidisciplinary team–based intervention designed to engage and retain in care the most severely impacted persons living with HIV/AIDS and experiencing homelessness.