摘要：Viruses can be spread and transmitted through two fundamental modes, one by virus-to-cell infection and the other by direct cell-to-cell transmission. In this paper, we propose a new generalized virus dynamics model, which incorporates both modes and takes into account the cure of infected cells. We first show mathematically and biologically the well-posedness of our model. Further, an explicit formula for the basic reproduction number R 0 $R_($ of the model is determined. By analyzing the characteristic equations we establish the local stability of the disease-free equilibrium and the chronic infection equilibrium in terms of R 0 $R_($ . The global behavior of the model is investigated by constructing an appropriate Lyapunov functional for disease-free equilibrium and by applying geometrical approach to chronic infection equilibrium. Moreover, mathematical virus models and results presented in many previous studies are generalized and improved.
