期刊名称：Epidemiology, Biostatistics and Public Health
印刷版ISSN：2282-0930
出版年度：2019
卷号：16
期号：1
页码：1-25
DOI：10.2427/13078
出版社：PREX
摘要：Background: Coffee consumption in relation to female hormone-related cancers has been investigated but metaanalyses
regarding breast and ovarian cancer include studies published up to 2012 with inconsistent results for
ovarian cancer.
Methods: We conducted two updated meta-analyses of studies published up to June 2016 to quantify the association
of coffee intake with breast and ovarian cancer risk with random effects models. We used the dataset developed by
the International Agency for Research on Cancer Working Group for Monograph 116 meeting (May 2016). We
additionally performed a PubMed search in June 2016.
Results: Summary relative risks (RRs) (95% confidence intervals (CI)) for the study-specific highest vs. lowest coffee
consumption were for breast and ovarian cancer respectively: 0.97 (0.93–1.00, Ι2 5.5%, 40 studies, 76,728
cases) and 1.03 (0.93–1.14, Ι
2 31.9%, 31 studies, 13,111 cases). For decaffeinated coffee the corresponding
RRs were: 1.00 (0.93-1.08, I2 32.2%, 13 studies) and 0.83 (0.71-0.96, I2 about 0%, 9 studies). The association
of coffee with ovarian cancer risk was higher among publications before (RR=1.37, 1.12–1.69) compared to after
2000 (RR=0.96, 0.86-1.06).
Conclusion: Our meta-analyses provide strong, quantitative evidence that coffee consumption is not related to breast
cancer risk and appears to be unrelated to ovarian cancer risk.
其他摘要：Background : Coffee consumption in relation to female hormone-related cancers has been investigated but metaanalyses regarding breast and ovarian cancer include studies published up to 2012 with inconsistent results for ovarian cancer. Methods : We conducted two updated meta-analyses of studies published up to June 2016 to quantify the association of coffee intake with breast and ovarian cancer risk with random effects models. We used the dataset developed by the International Agency for Research on Cancer Working Group for Monograph 116 meeting (May 2016). We additionally performed a PubMed search in June 2016. Results : Summary relative risks (RRs) (95% confidence intervals (CI)) for the study-specific highest vs. lowest coffee consumption were for breast and ovarian cancer respectively: 0.97 (0.93–1.00, Ι2 5.5%, 40 studies, 76,728 cases) and 1.03 (0.93–1.14, Ι 2 31.9%, 31 studies, 13,111 cases). For decaffeinated coffee the corresponding RRs were: 1.00 (0.93-1.08, I2 32.2%, 13 studies) and 0.83 (0.71-0.96, I2 about 0%, 9 studies). The association of coffee with ovarian cancer risk was higher among publications before (RR=1.37, 1.12–1.69) compared to after 2000 (RR=0.96, 0.86-1.06). Conclusion : Our meta-analyses provide strong, quantitative evidence that coffee consumption is not related to breast cancer risk and appears to be unrelated to ovarian cancer risk.
关键词：coffee; breast cancer; ovarian cancer; meta-analysis; review
