期刊名称：TELKOMNIKA (Telecommunication Computing Electronics and Control)
印刷版ISSN：2302-9293
出版年度：2019
卷号：17
期号：3
页码：1352-1359
DOI：10.12928/telkomnika.v17i3.11750
出版社：Universitas Ahmad Dahlan
摘要：Motif discovery in DNA sequences is one of the most important issues in bioinformatics.
Thus, algorithms for dealing with the problem accurately and quickly have always been the goal of
research in bioinformatics. Therefore, this study is intended to modify the random projection algorithm to
be implemented on R high performance computing (i.e., the R package pbdMPI). Some steps are needed
to achieve this objective, ie preprocessing data, splitting data according to number of batches, modifying
and implementing random projection in the pbdMPI package, and then aggregating the results. To validate
the proposed approach, some experiments have been conducted. Several benchmarking data were used
in this study by sensitivity analysis on number of cores and batches. Experimental results show that
computational cost can be reduced, which is that the computation cost of 6 cores is faster around 34 times
compared with the standalone mode. Thus, the proposed approach can be used for motif discovery
effectively and efficiently.
其他摘要：Motif discovery in DNA sequences is one of the most important issues in bioinformatics. Thus, algorithms for dealing with the problem accurately and quickly have always been the goal of research in bioinformatics. Therefore, this study is intended to modify the random projection algorithm to be implemented on R high performance computing (i.e., the R package pbdMPI). Some steps are needed to achieve this objective, ie preprocessing data, splitting data according to number of batches, modifying and implementing random projection in the pbdMPI package, and then aggregating the results. To validate the proposed approach, some experiments have been conducted. Several benchmarking data were used in this study by sensitivity analysis on number of cores and batches. Experimental results show that computational cost can be reduced, which is that the computation cost of 6 cores is faster around 34 times compared with the standalone mode. Thus, the proposed approach can be used for motif discovery effectively and efficiently.
关键词：bioinformatics;high performance computing;motif discovery;planted motif search;R programming language
