摘要：Introduction: Oxidative stress is largely responsible
for numerous skin complications that occur in the
course of various diseases as well as accelerated skin
aging. A high amino acid diet, supplemented with
whey protein concentrate (WPC), is well-balanced
and has well-absorbing proteins, which are an ideal
source of essential amino acids.
Purpose: To assess what changes will occur in the
antioxidant barrier of unharmed skin of rats on a high
amino acid diet.
Materials and methods: The study was conducted
on sexually mature male Wistar rats (160-180g): 1.
control (standard feed), 2. high amino acid diet
(WPC-80 80% whey protein) administered for 7
days at a dose of 0.3g/kg of body weight, 3. WPC80
for 7 days at a dose of 0.5g/kg of body weight, 4.
WPC-80 for 14 days at a dose of 0.3g/kg of body
weight, 5. WPC-80 for 14 days at a dose of 0.5g/kg
of body weight. Total antioxidant capacity, total
oxidative status and oxidative stress index were
determined.
Results: Enrichment of a standard diet with WPC80
did not affect the total oxidative status of
undamaged healthy rat skin. This study shows that a
diet rich in amino acids in rats caused an increase in
total antioxidant capacity, but statistically significant
values were obtained after 14 days of administering
WPC at a dose of 0.5mg/kg of body weight.
Conclusions: Enrichment of a standard diet with
WPC-80 strengthens the antioxidant barrier in
unwounded healthy rat skin.
关键词：Whey protein concentrate; oxidative stress; skin; rat
