摘要：Introduction: Glucagonoma is a rare
neuroendocrine tumor with characteristic features
such as the presence of the glucagon-producing
tumor, diabetes, and necrolytic migratory erythema.
Case presentation: the 60-year-old patient was
admitted to hospital with periodic pain in the right
and middle upper abdominal appearing after eating.
Laboratory tests presented a high glucose level and
anemia. Tumor of the body and tail of the pancreas
passing the organ pouch has been found during the
surgery. Diagnosis of glucagonoma was confirmed
in histopathological examination in
immunohistochemical stainings: a positive reaction
was observed with chromogranin, synaptophysin
and CEA. The proliferative activity of Ki-67 was
less than 1%. Staining for glucagon also was positive
so confirmed the presence of neuroendocrine tumor
- glucagonoma.
Conclusions: Glucagonoma sometimes may occur
without characteristic features which may cause
delayed diagnosis. Early diagnosis of glucagonoma
is important because it increases the chances of
successful recovery.
