This study was performed to compare macular retinal thickness measured by four different optical coherence tomography (OCT) devices.

Macular retinal thicknesses were measured in 32 healthy eyes of 32 subjects by using Cirrus HD-OCT (Carl Zeiss Meditec, Inc., Dublin, CA, USA), Spectralis OCT (Heidelberg engineering, Heidelberg, Germany), Topcon DRI OCT (Topcon Corp., Tokyo, Japan), and RS-3000 Advance OCT (Nidek, Co., Ltd., Gamagori, Japan). Macular retinal thickness measurements were compared among the devices.

Average macular retinal thickness ranged 288.7 to 313.3 µm ( p < 0.01). Differences in average macular retinal thickness among the devices ranged from 0.7 to 27.3 µm; the limit of agreement (LoA) ranged from 9.7 to 24.4 µm. Among the devices, comparison between Spectralis OCT and RS-3000 Advance OCT showed the smallest difference in average macular retinal thickness (mean, 0.7 µm) and the narrowest LoA (−6.4 to 3.3 µm).

Macular retinal thickness measured by four different OCT devices showed different values. However, values obtained by Spectralis OCT and RS-3000 Advance OCT showed good agreement.