摘要：Lactobacillus plantarum 299v is a probiotic bacterium effective in treating symptoms of irritable bowel syndrome. A mouse model of irritable bowel syndrome (IBS) can be produced by rectal administration of 1% allyl isothiocyanate (oil of mustard) in 30% ethanol. This study examined the effect of L. plantarum 299v on colonic inflammation and motility in the oil of mustard model. L. plantarum 299v (1×109 cfu) was gavaged for up to 28 days, beginning either 7 days before (pretreatment) or 8 days after oil of mustard administration (post-treatment). Colonic interferon gamma (IFNγ) release as an assessment of the inflammatory response was measured at day 4 and day 20 following oil of mustard administration. Small intestinal transit was assessed via the dye-transit score technique at day 20. L. plantarum 299v reduced inflammation at both day 4 and day 20 and normalized intestinal transit rates in the oil of mustard murine IBS model.
