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  • 标题:Lithium Binaphtholate-Catalyzed Michael Reaction of Malonates with Maleates and Its Application to the Enantioselective Synthesis of Tricarboxylic Acid Derivatives
  • 本地全文:下载
  • 作者:Midori Sakamoto ; Tetsuya Kaneko ; Yuya Orito
  • 期刊名称:Chemical and Pharmaceutical Bulletin
  • 印刷版ISSN:0009-2363
  • 电子版ISSN:1347-5223
  • 出版年度:2019
  • 卷号:67
  • 期号:5
  • 页码:452-460
  • DOI:10.1248/cpb.c18-00993
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:

    The Michael reaction of malonates with maleates afforded the corresponding adducts in high yields with high enantioselectivities (up to 98% enantiomeric excess (ee)) by using dilithium 3,3′-dichlorobinaphtholate as a catalyst. The obtained Michael adducts could be converted to optically active tricarboxylic acid (TCA) derivatives via the Krapcho reaction.

  • 关键词:Michael reaction;lithium binaphtholate;tricarboxylic acid ester;Krapcho reaction;stereoselectivity
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