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  • 标题:Genome-wide survey of interindividual differences of RNA stability in human lymphoblastoid cell lines
  • 本地全文:下载
  • 作者:Jubao Duan ; Jianxin Shi ; Xijin Ge
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2013
  • 卷号:3
  • 期号:1
  • DOI:10.1038/srep01318
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:The extent to which RNA stability differs between individuals and its contribution to the interindividual expression variation remain unknown. We conducted a genome-wide analysis of RNA stability in seven human HapMap lymphoblastoid cell lines (LCLs) and analyzed the effect of DNA sequence variation on RNA half-life differences. Twenty-six percent of the expressed genes exhibited RNA half-life differences between LCLs at a false discovery rate (FDR)
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