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  • 标题:On-Chip Cytometry using Plasmonic Nanoparticle Enhanced Lensfree Holography
  • 本地全文:下载
  • 作者:Qingshan Wei ; Euan McLeod ; Hangfei Qi
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2013
  • 卷号:3
  • 期号:1
  • DOI:10.1038/srep01699
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:Computational microscopy tools, in particular lensfree on-chip imaging, provide a large field-of-view along with a long depth-of-field, which makes it feasible to rapidly analyze large volumes of specimen using a compact and light-weight on-chip imaging architecture. To bring molecular specificity to this high-throughput platform, here we demonstrate the use of plasmon-resonant metallic nanoparticles to automatically recognize different cell types based on their plasmon-enhanced lensfree holograms, detected and reconstructed over a large field-of-view of e.g., ~24 mm2.
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