文章基本信息
- 标题：T1R3: A human calcium taste receptor
- 本地全文：下载
- 作者：Michael G. Tordoff ; Laura K. Alarcón ; Sitaram Valmeki 等
- 期刊名称：Scientific Reports
- 电子版ISSN：2045-2322
- 出版年度：2012
- 卷号：2
- 期号：1
- DOI：10.1038/srep00496
- 语种：English
- 出版社：Springer Nature
- 摘要：
Many animals can detect the taste of calcium but it is unclear how or whether humans have this ability. We show here that calcium activates hTAS1R3-transfected HEK293 cells and that this response is attenuated by lactisole, an inhibitor of hT1R3. Moreover, trained volunteers report that lactisole reduces the calcium intensity of calcium lactate. Thus, humans can detect calcium by taste, T1R3 is a receptor responsible for this, and lactisole can reduce the taste perception of calcium by acting on T1R3.
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