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文章基本信息

  • 标题:Visualisation of newly synthesised collagen in vitro and in vivo
  • 本地全文:下载
  • 作者:Corien Oostendorp ; Peter J.E. Uijtdewilligen ; Elly M. Versteeg
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2016
  • 卷号:6
  • 期号:1
  • DOI:10.1038/srep18780
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:Identifying collagen produced de novo by cells in a background of purified collagenous biomaterials poses a major problem in for example the evaluation of tissue-engineered constructs and cell biological studies to tumor dissemination. We have developed a universal strategy to detect and localize newly deposited collagen based on its inherent association with dermatan sulfate. The method is applicable irrespective of host species and collagen source.
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