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  • 标题:High-throughput compound evaluation on 3D networks of neurons and glia in a microfluidic platform
  • 本地全文:下载
  • 作者:Nienke R. Wevers ; Remko van Vught ; Karlijn J. Wilschut
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2016
  • 卷号:6
  • 期号:1
  • DOI:10.1038/srep38856
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:With great advances in the field of in vitro brain modelling, the challenge is now to implement these technologies for development and evaluation of new drug candidates. Here we demonstrate a method for culturing three-dimensional networks of spontaneously active neurons and supporting glial cells in a microfluidic platform. The high-throughput nature of the platform in combination with its compatibility with all standard laboratory equipment allows for parallel evaluation of compound effects.
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