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  • 标题:Potent Inducers of Endogenous Antimicrobial Peptides for Host Directed Therapy of Infections
  • 本地全文:下载
  • 作者:H. Ottosson ; F. Nylén ; P. Sarker
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2016
  • 卷号:6
  • 期号:1
  • DOI:10.1038/srep36692
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:A new concept for treatment of infections is induction of our own antimicrobial peptides and the presented novel class of inducer, aroylated phenylenediamines (APDs), gives up to 20 to 30-fold induction of the human antimicrobial peptide LL-37, in vitro. In addition, oral administration of an APD in a rabbit model of Shigellosis resulted in recovery from the infection in a few days implying that APD's are promising candidates for treatment of infections.
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