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  • 标题:Thumb Imprint Based Detection of Hyperbilirubinemia Using Luminescent Gold Nanoclusters
  • 本地全文:下载
  • 作者:Srestha Basu ; Amaresh Kumar Sahoo ; Anumita Paul
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2016
  • 卷号:6
  • 期号:1
  • DOI:10.1038/srep39005
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:Early and easy detection of diseases, using point-of-care and inexpensive devices, not only provides option for early treatment but also reduces the risk of propagation. Herein we report the fabrication of a robust film based luminescence indicator of bilirubin, which can indicate hyperbilirubinemia through the thumb imprint of the patient. The UV-light induced luminescence intensity of the film, made out of chitosan stabilised gold (Au) nanoclusters, which was effectively quenched in the presence of Cu(2+) ions, recovered in the presence of bilirubin from skin or blood serum. Moreover, the sensitivity of detection of bilirubin was tuneable with the amount of Cu(2+) added, thereby facilitating the detection of the desired concentration range of bilirubin.
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