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  • 标题:Roles of small RNAs in the effects of nutrition on apoptosis and spermatogenesis in the adult testis
  • 本地全文:下载
  • 作者:Yongjuan Guan ; Guanxiang Liang ; Penelope A. R. Hawken
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2015
  • 卷号:5
  • 期号:1
  • DOI:10.1038/srep10372
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:We tested whether reductions in spermatozoal quality induced by under-nutrition are associated with increased germ cell apoptosis and disrupted spermatogenesis, and whether these effects are mediated by small RNAs. Groups of 8 male sheep were fed for a 10% increase or 10% decrease in body mass over 65 days. Underfeeding increased the number of apoptotic germ cells (P TP53 , CASP3 , FASL ). The proportion of miRNAs as a total of small RNAs was greater in well-fed males than in underfed males (P
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