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  • 标题:Transmission of tularemia from a water source by transstadial maintenance in a mosquito vector
  • 本地全文:下载
  • 作者:Stina Bäckman ; Jonas Näslund ; Mats Forsman
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2015
  • 卷号:5
  • 期号:1
  • DOI:10.1038/srep07793
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:Mosquitoes are thought to function as mechanical vectors of Francisella tularensis subspecies holarctica ( F. t. holarctica ) causing tularemia in humans. We investigated the clinical relevance of transstadially maintained F. t. holarctica in mosquitoes. Aedes egypti larvae exposed to a fully virulent F. t. holarctica strain for 24 hours, were allowed to develop into adults when they were individually homogenized. Approximately 24% of the homogenates tested positive for F. t. DNA in PCR. Mice injected with the mosquito homogenates acquired tularemia within 5 days. This novel finding demonstrates the possibility of transmission of bacteria by adult mosquitoes having acquired the pathogen from their aquatic larval habitats.
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