摘要：Repeated exposure to the same stimulus results in an attenuated brain response in cortical regions that are activated during the processing of that stimulus. This phenomenon, called repetition suppression (RS), has been shown to be modulated by expectation. Typically, this is achieved by varying the probability of stimulus repetitions (Prep) between blocks of an experiment, generating an abstract expectation that 'things will repeat'. Here, we examined whether stimulus-specific expectations also modulate RS. We designed a task where expectation and repetition are manipulated independently, using stimulus-specific expectations. We investigated to which extent such stimulus-specific expectations modulated the visual evoked response to objects in lateral occipital cortex (LOC) and primary visual cortex (V1), using functional magnetic resonance imaging (fMRI). In LOC, we found that RS interacted with expectation, such that repetition suppression was more pronounced for unexpected relative to expected stimuli. Additionally, we found that the response of stimulus-preferring voxels in V1 was generally decreased when stimuli were expected. These results suggest that stimulus-specific expectations about objects modulate LOC and propagate back to the earliest cortical station processing visual input.
