期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2019
卷号：116
期号：23
页码：11490-11495
DOI：10.1073/pnas.1818871116
出版社：The National Academy of Sciences of the United States of America
摘要：Recent evidence implicates dysregulation of metabotropic glutamatergic receptor 5 (mGluR5) in pathophysiology of PTSD and suicidality. Using positron emission tomography and [18F]FPEB, we quantified mGluR5 availability in vivo in individuals with PTSD ( n = 29) and MDD ( n = 29) as a function of suicidal ideation (SI) to compare with that of healthy comparison controls (HC; n = 29). Volume of distribution was computed using a venous input function in the five key frontal and limbic brain regions. We observed significantly higher mGluR5 availability in PTSD compared with HC individuals in all regions of interest ( P ’s = 0.001–0.01) and compared with MDD individuals in three regions ( P ’s = 0.007). mGluR5 availability was not significantly different between MDD and HC individuals ( P = 0.17). Importantly, we observed an up-regulation in mGluR5 availability in the PTSD-SI group ( P ’s = 0.001–0.007) compared with PTSD individuals without SI. Findings point to the potential role for mGluR5 as a target for intervention and, potentially, suicide risk management in PTSD.
