期刊名称：IOP Conference Series: Earth and Environmental Science
印刷版ISSN：1755-1307
电子版ISSN：1755-1315
出版年度：2019
卷号：252
期号：2
页码：1-5
DOI：10.1088/1755-1315/252/2/022090
出版社：IOP Publishing
摘要：7-fluoroquinazoline-2, 4-diol is an important intermediate of small molecule anticancer drugs. In this work, a rapid synthetic method for target compounds was established. Compound (4) was synthesized from 2-amino-4-fluoro benzoic acid and urea through three steps including cyclization, chlorination and nucleophilic substitution. The structure of the target compound was confirmed by H NMR and MS spectrum. Furthermore, the synthetic method was optimized. The total yield of the three steps was 51%.
