期刊名称：IOP Conference Series: Earth and Environmental Science
印刷版ISSN：1755-1307
电子版ISSN：1755-1315
出版年度：2019
卷号：252
期号：2
页码：1-5
DOI：10.1088/1755-1315/252/2/022091
出版社：IOP Publishing
摘要：2, 4-dichloro-6-(3-nitrophenoxy) pyrimidine is an important intermediate of small molecule anticancer drugs. In this work, a rapid synthetic method for target compounds was established. Compound (4) was synthesized from methyl 3-aminothiophene-2-carboxylate and urea through three steps including cyclization, chlorination and nucleophilic substitution. The structure of the target compound was confirmed by 1H NMR and MS spectrum. Furthermore, the synthetic method was optimized. The total yield of the three steps was 42.4%.
