摘要：Decreased inhibition control ability and increased craving may be the most important causes of relapsing in smoking. Although inhibition control defects in young smokers were investigated, the effects of short-term abstinence on inhibition control in young smokers were still unclear. Thirty young smokers participated in the present study. The EEG signals during the Go/NoGo task were recorded in both satiety and 12 hour abstinence conditions. The task performances were observed and compared between the two conditions. Event-related potential (ERP) analysis was used to investigate changes in N200 and P300 amplitude and latency induced by 12 hours of abstinence. After 12 hours of abstinence, the latency of N200 was prolonged in young smokers. No significant changes were found in the number of NoGo errors and the response time of Go in young smokers after 12 hours of abstinence. Correlation analysis showed that the N200 latency of abstinence condition was significantly correlated with the number of NoGo errors and the response time of Go in the abstinence condition. The present findings may improve the understanding of the effect of short-term abstinence in young smokers. We suggested that the latency of N200 may be associated with inefficient inhibitory control of the abstinence condition in young smokers. Our results may contribute new insights into the neural mechanism of nicotine abstinence in young smokers.
关键词：event-related potentials (ERP); Young smokers; 12-h abstinence; go/nogo task; inhibition control
