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  • 标题:Reply to Velavan et al.: Polymorphisms of pfcoronin in natural populations: Implications for functional significance
  • 本地全文:下载
  • 作者:Aabha I. Sharma ; Allison R. Demas ; Daniel L. Hartl
  • 期刊名称:Proceedings of the National Academy of Sciences
  • 印刷版ISSN:0027-8424
  • 电子版ISSN:1091-6490
  • 出版年度:2019
  • 卷号:116
  • 期号:26
  • 页码:12613-12614
  • DOI:10.1073/pnas.1907920116
  • 出版社:The National Academy of Sciences of the United States of America
  • 摘要:Velavan et al. (1) describe work that they have carried out based on our recent PNAS publication, “Mutations in Plasmodium falciparum actin-binding protein coronin confer reduced artemisinin susceptibility” (2). Among 297 patient samples from 4 countries in Africa, they found 12 polymorphic amino acid sites in Pf Coronin, 7 observed only among 48 parasites from the Congo (1). These findings are consistent with results reported in the Pf3k database (https://www.malariagen.net/projects/p-falciparum-communityproject), which we referenced in our original publication. The amino acid replacements of Pf Coronin that we found to be .
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