期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2019
卷号：116
期号：36
页码：17631-17631
DOI：10.1073/pnas.1905970116
出版社：The National Academy of Sciences of the United States of America
摘要：We read with great interest the study by Jorgenson et al. (1), which demonstrated that genetic variation in the SIM1 locus is associated with erectile dysfunction (ED). This large and ethnically diverse genome-wide association study (GWAS) provides strong evidence for the significance of rs17185536 in SIM1 with ED risk. However, we highlight some concerns. First, ED is highly susceptible to environmental factors, social relationships, or spousal relationships, while less impacted by genetic factors (1, … [↵][1]1To whom correspondence may be addressed.
