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  • 标题:Increased Rac1 Activation in the Enhanced Carbachol-Induced Bronchial Smooth Muscle Contraction of Repeatedly Antigen-Challenged Mice
  • 本地全文:下载
  • 作者:Yuki Kai ; Momoko Motegi ; Yuta Suzuki
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:2019
  • 卷号:42
  • 期号:9
  • 页码:1605-1607
  • DOI:10.1248/bpb.b19-00404
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:

    Recently, we demonstrated that Rac1 upregulation is involved in augmented bronchial smooth muscle (BSM) contractions of antigen-challenged mice. However, change in G protein-coupled receptor (GPCR)-induced Rac1 activation remains unknown in BSMs of repeatedly antigen-challenged (Chal.) mice. We here examined carbachol (CCh)-induced Rac1 activation in BSMs of Chal. mice. Gene expression levels of both Rac1 and Rac -guanine nucleotide exchange factors (GEFs), such as Tiam1 and Trio , were increased in BSMs of Chal. mice. Furthermore, CCh-induced Rac1 activation was inhibited by pretreatment with Rac1-GEF inhibitor NSC23766 and Rac1 inhibitor EHT1864 in BSMs of sensitized-control (S.C.) and Chal. mice. Compared with S.C. mice, CCh-induced Rac1 activation was increased in BSMs of Chal. mice. In conclusion, we reported that increased CCh-induced Rac1 activation via Tiam1 and Trio upregulation, in addition to upregulate Rac1 , may be involved in increased CCh-induced BSM contractions in Chal. mice.

  • 关键词:bronchial smooth muscle;carbachol;asthma;Rac1;Rac-guanine nucleotide exchange factor (GEF)
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