首页    期刊浏览 2024年11月28日 星期四
登录注册

文章基本信息

  • 标题:Asymmetric Total Syntheses and Structure Elucidations of (+)-Eurotiumide F and (+)-Eurotiumide G
  • 本地全文:下载
  • 作者:Atsushi Nakayama ; Hideo Sato ; Shuji Nagano
  • 期刊名称:Chemical and Pharmaceutical Bulletin
  • 印刷版ISSN:0009-2363
  • 电子版ISSN:1347-5223
  • 出版年度:2019
  • 卷号:67
  • 期号:9
  • 页码:953-958
  • DOI:10.1248/cpb.c18-00948
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:

    Asymmetric total syntheses of dihydropyran containing natural products, (+)-eurotiumide F and (+)-eurotiumide G have been described. These total syntheses revealed the absolute configuration of eurotiumide F and G, and confirmed the reported structure of eurotiumide F and revised the reported structure of eurotiumide G. Highlight of these syntheses is thermal rearrangement with 4-methoxyisochroman-1-one derivative having propargyl ether on phenolic ether under thermal condition to construct dihydropyran ring. X-Ray crystallographic analysis of (+)-eurotiumide G clarified the stereochemistry at the C1-position.

  • 关键词:total synthesis;natural product;dihydropyran
国家哲学社会科学文献中心版权所有