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  • 标题:Rosanortriterpene C, a 3,24-Dinor-2,4-seco-ursane Triterpene from the Fruits of Rosa laevigata var. leiocapus
  • 本地全文:下载
  • 作者:Yunong Tian ; Lu Feng ; Bailin Li
  • 期刊名称:Chemical and Pharmaceutical Bulletin
  • 印刷版ISSN:0009-2363
  • 电子版ISSN:1347-5223
  • 出版年度:2019
  • 卷号:67
  • 期号:11
  • 页码:1255-1258
  • DOI:10.1248/cpb.c19-00648
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:

    One new 3,24-dinor-2,4- seco -ursane triterpene, rosanortriterpene C ( 1 ), together with four known compounds including 24-norursane-type nortriterpenes ( 2 – 3 ), 24-noroleanane-type nortriterpene ( 4 ), ursane-type triterpene ( 5 ), was isolated from the fruits of Rosa laevigata var. leiocapus . The new structure was elucidated through comprehensive spectroscopic analysis, including one dimensional (1D) and 2D NMR data, as well as electrospray ionization high resolution (HR-ESI) MS and IR spectrometry. Compounds 1 – 5 showed moderate anti-inflammatory activities against the production of nitric oxide (NO) in RAW264.7 cells stimulated by lipopolysaccharide (LPS) with IC50 values of 10.35 ± 0.92, 14.28 ± 1.20, 5.04 ± 1.43, 29.29 ± 3.64, and 14.37 ± 0.59 µM, respectively.

  • 关键词:ursane-type nortriterpene;oleanane-type nortriterpene;Rosa laevigata var. leiocapus;anti-inflammatory
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