Temperature stability was taken as the evaluation index of processing performance, and the three factors that influence normal milk processing and mixing performance were optimized by response surface analysis and BP‐GA neural network algorithm. Analysis results showed the influence order of the factors on temperature stability was as follows: shape > height > rotating speed. In the optimization by response surface methodology (RSM), when rotating speed was 30 r/min, height was 31 mm, and blade shape was a full trapezoid, predicted value and actual value of variable coefficient were 0.0046 and 0.0044 respectively, with relative error of 4.5%. In the optimization by BP‐GA neural network algorithm, when rotating speed was 34 r/min, height was 25 mm, and blade shape was a full trapezoid, the predicted value and actual value of variable coefficient were 0.0036 and 0.0035 respectively, with relative error of 2.9%. The predicted root‐mean‐square error of the model by the BP‐GA neural network algorithm was 0.0013, determination coefficient was 0.9960, and relative percent deviation was 8.4961, which showed better performance than the RSM model. Thus, the BP‐GA neural network algorithm has better fitting performance, and then, the optimal working parameter combination was confirmed, which could provide reference to improving double‐blade normal milk processing and mixing device design and milk processing quality.