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  • 标题:1,4-Naphthoquinones: Some Biological Properties and Application
  • 本地全文:下载
  • 作者:Dmitry Aminin ; Sergey Polonik
  • 期刊名称:Chemical and Pharmaceutical Bulletin
  • 印刷版ISSN:0009-2363
  • 电子版ISSN:1347-5223
  • 出版年度:2020
  • 卷号:68
  • 期号:1
  • 页码:46-57
  • DOI:10.1248/cpb.c19-00911
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:

    Over the past decade, a number of new 1,4-naphthoquinones have been isolated from natural sources and new 1,4-naphthoquinones with diverse structural features have been synthesized. Cardioprotective, anti-ischemic, hepatoprotective, neuroprotective and some other new properties were found for these compounds; their role in protecting against neurodegenerative diseases has been established. Their anti-inflammatory, antimicrobial and antitumor activities have been studied in more detail; new, previously unknown intracellular molecular targets and mechanisms of action have been discovered. Some compounds of this class are already being used as a medicinal drugs and some substances can be used as biochemical tools and probes for non-invasive detection of pathological areas in cells and tissues in myocardial infarction and neurodegenerative diseases using modern molecular imaging techniques.

  • 关键词:1;4-naphthoquinone;chemical structure;biological property;molecular target
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