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  • 标题:Metal-Free Oxidative Cross-Coupling Reaction of Heteroaromatic and Related Compounds
  • 本地全文:下载
  • 作者:Koji Morimoto
  • 期刊名称:Chemical and Pharmaceutical Bulletin
  • 印刷版ISSN:0009-2363
  • 电子版ISSN:1347-5223
  • 出版年度:2019
  • 卷号:67
  • 期号:12
  • 页码:1259-1270
  • DOI:10.1248/cpb.c19-00286
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:

    The biary unit having heteroatom as important scaffolds widely exist in a large number of biologically active compounds and functional organic molecules. Since the cross-coupling is a useful synthetic method for constructing biaryl and heterobiaryl structures, the development of novel cross-coupling methods has been studied intensively. The oxidative biaryl coupling reaction of aromatic compounds having heteroatoms is an attractive method since they do not require the prefunctionalization of arenes. This report describes recent advances in hypervalent iodine(III) induced metal-free synthesis of biaryls having heteroatoms.

  • 关键词:cross-coupling;hypervalent iodine(III);heteroatom
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