The exergoeconomic analysis is a powerful tool to study an energy system and provide rational decision‐making for it. This paper is aimed at exergoeconomic optimization and sensitivity analysis evaluation of the results of a commercial parabolic trough collector (PTC). First, an analysis of optical, thermal, exergy, and economic equations of the PTC system is presented. Then, the objective function and variables are optimized through MATLAB software using the hybrid algorithm code. The objective function as the exergy loss rate is a combination of exergy loss and system cost. The evaluation of the results has been carried out considering the radiation intensity in different months of the year for Tehran, Iran. The commercial parabolic trough solar collector has been selected as the case study. Sensitivity analysis of exergy loss rate and exergy efficiency was conducted for important variables, namely collector length, the glass cover diameter, the outer diameter of absorber tube, the inner diameter of absorber, the fluid inlet temperature, the receiver aperture width, and fluid flow rate. The obtained results show that the exergy loss rate is 0.1905 kW/$, and the exergy efficiency is equal to 15.2% for the highest direct solar radiation of 674 .