The therapeutic approach of patients diagnosed with type 2 diabetes is complex and multidisciplinary. Complementary to specific medication, patients’ self-management education and support became key interventions to empower an individual to engage in healthy lifestyle behaviours. Evidence suggests that there are many barriers to successfully integrating these strategies into clinical practice. Also, therapy is more efficient when people get support to continually engage in effective self-management behaviours. Through a case-study research, we aimed to explore the impact of an individualized occupation-based support intervention on the clinical state and quality of life of a 43 years old woman with type 2 diabetes, obesity, and retinopathy. Following the initial assessment of functional status, quality of life, performance, and satisfaction in daily occupations, a six months intervention plan was developed. Through therapeutic education, time management and occupation analyse, we considered integrating the therapeutic recommendations (drugs administration, weight control, blood glucose monitoring, and physical activity) into the daily routine of our client. After revaluation, the obtained results indicate significant improvements in the client’s occupational profile, health, and quality of life. Our study provides evidence that supports the beneficial role of the proposed occupational therapy intervention in the clinical management of the patient with type 2 diabetes.