期刊名称：Journal of Materials and Environmental Science
印刷版ISSN：2028-2508
出版年度：2017
卷号：8
期号：11
页码：3855-3863
出版社：University of Mohammed Premier Oujda
摘要：A new series of 5-alkoxymethyl-8-hydroxyquinoline, 5-alkyaminomethyl-8-hydroxy-quinoline, 5-alkylthio-methyl-8-hydroxyquinoline were synthesized starting from 5-chloromethyl-8-hydroxyquinoline and identified using spectral analysis IR, 1H NMR and 13C NMR. The newly synthesized compounds were evaluated and screened “in vitro” for antibacterial activities against Gram-positive and Gram-negative bacterial strains; the preliminary screening results showed that the series of the alkylthiomethyl-8-hydroxyquinoline present a significant antibacterial activity when compared to the standard antibiotic, Nitroxoline. Furthermore, the synthesized compounds demonstrated moderate antioxidant activities at a low compared with to the ascorbic acid by free radical scavenging method with 2,2-diphenyl-1-picrylhydrazyl (DPPH).
关键词：8;hydroxyquinoline; Synthesis; Characterization; In vitro; Activity; Antibacterial; Antioxidant.
