期刊名称：Journal of Materials and Environmental Science
印刷版ISSN：2028-2508
出版年度：2018
卷号：9
期号：9
页码：2575-2586
出版社：University of Mohammed Premier Oujda
摘要：The present study aims to evaluate phytoconstituents of Lagerstromia indica (L.) and theireffect on Alzheimer's disease (AD). HPLC was ( carried out) for identification ofphenolics, flavonoids and natural pigments. Seven phenolic acids were identified in thisinvestigation for the first time; ferulic, cinnamic, vanillic, p-hydroxy benzoic p–coumaric,caffeic and p-amino benzoic acids. The result of this investigation stated a promising effectof the 80% ethanolic extract (total extract) of L. indica as anti-Alzheimer's agent. In vivoexperiment using rats animal model to induce AD using aluminium cholride (Al Cl3)indicated disturbances in neurotransmitter levels including norepinephrine (NEp),acetylcholine esterase (AChE), dopamine (DA) and serotonin (5-HT). In addition,elevation in oxidative stress protein carbonyl (PC) and apoptotic markers caspase -3 werealso recorded. Histopathological investigation of AD induced rats showed cerebral cortexwith necrosis, atrophy, pyknosis of neurons and focal gliosis. Meanwhile, hippocampusof AD rats showed necrosis of pyramidal cells. On the other hand, hippocampus of ADrats treated with L. indica showed necrosis of some pyramidal cells. Treatment of cerebralcortex or hippocampus of AD rats treated with L. indica total extract showed necrosis ofsome sporadic neurons and pyramidal cells respectively. Hence, it could be concluded that,L. indica exhibited neuro-modulating effect in Al–induced neurotoxicity, which could beused in a future as a promising candidate nutraceuticals.
